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. 2023 Jan 24;16(2):175. doi: 10.3390/ph16020175

Figure 2.

Figure 2

The influence of JJGW07 on the number of punished crossings (Panel (A)), the number of buried marbles (Panel (B)), and time spent in the open arms (Panel (C)), as well as the number of entries into open arms (Panel (D)). (A) Mice were placed in the four-plate apparatus, and after a 15 s adaptation period, each crossing from one plate to another was punished by an electric shock. The number of punished crossings was measured for 60 s. (B) Mice were placed individually in cages with a 5 cm bedding layer, where 20 glass balls were placed. The number of buried marbles after 30 min of the test was counted. (C,D) In the elevated plus maze test, mice were placed individually in the center area of the maze and observed for 5 min. The number of entries into the open arms, as well as the time spent in the open arms, was measured. JJGW07 was administered intraperitoneally (ip) 30 min before the test. The control group received an injection of 0.9% NaCl (ip). Values are expressed as means ± SD; n = 8 mice per group. Statistical analysis: one-way ANOVA (Newman–Keuls post hoc), * p < 0.05, ** p < 0.01 vs. control group, FPT—the four-plate test, MBT—the marble-burying test, and EPM—the elevated plus maze test.