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. 2023 Jan 24;16(2):175. doi: 10.3390/ph16020175

Figure 3.

Figure 3

The effect of JJGW07 on the MK-801-induced (Panel (A)) and amphetamine-induced (Panel (B)) hyperlocomotion in mice. Locomotor activity was recorded in actometers separately for each mouse. After 30 min of adaptation, the number of crossings of photobeams was measured during 60 min. JJGW07 was administered intraperitoneally (ip) 30 min before the test. MK-801 (0.2 mg/kg, ip) was administered 15 min before the experiment, while amphetamine (2.5 mg/kg) was administered subcutaneously (sc) 30 min before the experiment. The control groups received either two injections of 0.9% NaCl (ip or sc), or 0.9% NaCl (ip) and MK-801 (ip), or 0.9% NaCl (ip) and amphetamine (sc). Values are expressed as means ± SD; n = 8–10 mice per group. Statistical analysis: one-way ANOVA (Newman–Keuls post hoc); ** p < 0.01, *** p < 0.001, **** p < 0.0001.