Table 1.
Transcripts significantly up-regulated in human retinal endothelial cells following both treatment with IL-1β and treatment with TNF-α for 60 min (n = 5 isolates).
| Ensembl Gene ID | Gene Symbol | Description | Treatment with IL-1β | Treatment with TNF-α | ||
|---|---|---|---|---|---|---|
| log2 Fold Change | FDR | log2 Fold Change | FDR | |||
| ENSG00000226380 | AC016831.1 | novel transcript | 1.38 | 1.81 × 10−7 | 1.06 | 1.83 × 10−5 |
| ENSG00000253837 | AC090197.1 | novel transcript | 1.51 | 2.74 × 10−7 | 1.55 | 2.51 × 10−7 |
| ENSG00000269902 | AC234772.2 | novel transcript | 1.52 | 2.65 × 10−4 | 1.23 | 5.35 × 10−3 |
| ENSG00000269906 | AL606834.1 | novel transcript, sense intronic to SAV1 | 1.19 | 8.21 × 10−4 | 1.14 | 1.93 × 10−3 |
| ENSG00000279903 | AP006248.3 | SLC7A2 intronic transcript 1 | 2.88 | 2.28 × 10−5 | 2.69 | 8.16 × 10−5 |
| ENSG00000279932 | AP006248.4 | novel transcript, sense intronic SLC7A2 | 2.37 | 3.32 × 10−4 | 2.31 | 6.35 × 10−4 |
| ENSG00000162772 | ATF3 | activating transcription factor 3 | 1.87 | 5.22 × 10−4 | 1.50 | 7.87 × 10−3 |
| ENSG00000095739 | BAMBI | BMP and activin membrane bound inhibitor | 1.36 | 2.73 × 10−3 | 1.16 | 1.89 × 10−2 |
| ENSG00000140379 | BCL2A1 | BCL2 related protein A1 | 2.49 | 1.77 × 10−4 | 1.98 | 5.17 × 10−3 |
| ENSG00000023445 | BIRC3 | baculoviral IAP repeat containing 3 | 3.13 | 4.15 × 10−6 | 2.61 | 6.87 × 10−5 |
| ENSG00000159388 | BTG2 | BTG anti-proliferation factor 2 | 1.60 | 2.07 × 10−5 | 1.18 | 1.74 × 10−3 |
| ENSG00000205502 | C2CD4B | C2 calcium dependent domain containing 4B | 3.56 | 7.38 × 10−9 | 3.34 | 3.14 × 10−8 |
| ENSG00000108691 | CCL2 | C-C motif chemokine ligand 2 | 1.95 | 1.87 × 10−3 | 1.82 | 5.51 × 10−3 |
| ENSG00000115009 | CCL20 | C-C motif chemokine ligand 20 | 6.15 | 7.28 × 10−9 | 5.14 | 2.06 × 10−7 |
| ENSG00000110848 | CD69 | CD69 molecule | 4.10 | 1.83 × 10−9 | 3.69 | 1.40 × 10−8 |
| ENSG00000112149 | CD83 | CD83 molecule | 3.29 | 8.88 × 10−8 | 2.69 | 2.95 × 10−6 |
| ENSG00000179862 | CITED4 | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 | 1.47 | 1.72 × 10−2 | 1.52 | 2.04 × 10−2 |
| ENSG00000164400 | CSF2 | colony stimulating factor 2 | 7.54 | 2.74 × 10−7 | 6.32 | 7.27 × 10−6 |
| ENSG00000006210 | CX3CL1 | C-X3-C motif chemokine ligand 1 | 1.18 | 2.68 × 10−2 | 1.24 | 2.80 × 10−2 |
| ENSG00000163739 | CXCL1 | C-X-C motif chemokine ligand 1 | 3.08 | 3.27 × 10−6 | 2.78 | 1.89 × 10−5 |
| ENSG00000081041 | CXCL2 | C-X-C motif chemokine ligand 2 | 5.97 | 2.73 × 10−9 | 5.07 | 3.05 × 10−8 |
| ENSG00000163734 | CXCL3 | C-X-C motif chemokine ligand 3 | 6.15 | 2.12 × 10−11 | 5.36 | 2.52 × 10−10 |
| ENSG00000169429 | CXCL8 | C-X-C motif chemokine ligand 8 | 3.11 | 1.50 × 10−5 | 2.87 | 5.41 × 10−5 |
| ENSG00000169242 | EFNA1 | ephrin A1 | 2.44 | 8.23 × 10−7 | 2.34 | 2.64 × 10−6 |
| ENSG00000235947 | EGOT | eosinophil granule ontogeny transcript | 3.34 | 2.46 × 10−7 | 2.73 | 9.42 × 10−6 |
| ENSG00000179388 | EGR3 | early growth response 3 | 1.60 | 7.94 × 10−3 | 1.40 | 3.28 × 10−2 |
| ENSG00000117525 | F3 | coagulation factor III, tissue factor | 2.39 | 4.24 × 10−3 | 2.07 | 2.28 × 10−2 |
| ENSG00000125740 | FOSB | FosB proto-oncogene, AP-1 transcription factor subunit | 2.09 | 3.44 × 10−3 | 1.78 | 2.25 × 10−2 |
| ENSG00000164949 | GEM | GTP binding protein overexpressed in skeletal muscle | 2.80 | 3.87 × 10−7 | 1.98 | 1.05 × 10−4 |
| ENSG00000090339 | ICAM1 | intercellular adhesion molecule 1 | 1.52 | 1.57 × 10−3 | 1.31 | 9.16 × 10−3 |
| ENSG00000137331 | IER3 | immediate early response 3 | 2.17 | 3.52 × 10−5 | 1.68 | 1.26 × 10−3 |
| ENSG00000162783 | IER5 | immediate early response 5 | 1.25 | 1.31 × 10−3 | 1.09 | 7.95 × 10−3 |
| ENSG00000115604 | IL18R1 | interleukin 18 receptor 1 | 2.22 | 4.07 × 10−5 | 1.95 | 3.22 × 10−4 |
| ENSG00000115008 | IL1A | interleukin 1 alpha | 3.11 | 4.29 × 10−6 | 2.70 | 4.97 × 10−5 |
| ENSG00000136244 | IL6 | interleukin 6 | 2.79 | 8.46 × 10−5 | 2.29 | 1.30 × 10−3 |
| ENSG00000125347 | IRF1 | interferon regulatory factor 1 | 3.21 | 3.32 × 10−8 | 2.96 | 2.06 × 10−7 |
| ENSG00000171223 | JUNB | JunB proto-oncogene, AP-1 transcription factor subunit | 1.37 | 3.66 × 10−3 | 1.21 | 1.87 × 10−2 |
| ENSG00000132510 | KDM6B | lysine demethylase 6B | 1.93 | 3.54 × 10−6 | 1.65 | 5.32 × 10−5 |
| ENSG00000237892 | KLF7-IT1 | KLF7 intronic transcript 1 | 1.57 | 2.34 × 10−7 | 1.62 | 2.14 × 10−7 |
| ENSG00000128342 | LIF | LIF interleukin 6 family cytokine | 3.19 | 1.78 × 10−7 | 2.26 | 4.42 × 10−5 |
| ENSG00000261618 | LINC02605 | long intergenic non-protein coding RNA 2605 | 4.54 | 1.42 × 10−8 | 3.42 | 4.85 × 10−6 |
| ENSG00000107968 | MAP3K8 | mitogen-activated protein kinase kinase kinase 8 | 1.31 | 5.19 × 10−3 | 1.26 | 1.01 × 10−2 |
| ENSG00000234883 | MIR155HG | MIR155 host gene | 2.59 | 9.02 × 10−6 | 2.32 | 7.05 × 10−5 |
| ENSG00000253522 | MIR3142HG | MIR3142 host gene | 3.00 | 2.42 × 10−8 | 2.66 | 2.51 × 10−7 |
| ENSG00000163121 | NEURL3 | neuralized E3 ubiquitin protein ligase 3 | 1.92 | 2.65 × 10−3 | 2.16 | 7.87 × 10−4 |
| ENSG00000100906 | NFKBIA | NFKB inhibitor alpha | 3.06 | 1.83 × 10−9 | 2.63 | 1.93 × 10−8 |
| ENSG00000144802 | NFKBIZ | NFKB inhibitor zeta | 2.77 | 7.63 × 10−10 | 1.78 | 4.53 × 10−7 |
| ENSG00000151014 | NOCT | nocturnin | 1.91 | 3.54 × 10−6 | 1.73 | 2.20 × 10−5 |
| ENSG00000163545 | NUAK2 | NUAK family kinase 2 | 3.63 | 2.97 × 10−9 | 3.48 | 1.40 × 10−8 |
| ENSG00000141682 | PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 1.11 | 8.77 × 10−4 | 1.03 | 2.82 × 10−3 |
| ENSG00000087074 | PPP1R15A | protein phosphatase 1 regulatory subunit 15A | 1.26 | 7.28 × 10−9 | 1.04 | 2.51 × 10−7 |
| ENSG00000073756 | PTGS2 | prostaglandin-endoperoxide synthase 2 | 1.49 | 1.81 × 10−4 | 1.23 | 2.54 × 10−3 |
| ENSG00000159200 | RCAN1 | regulator of calcineurin 1 | 1.54 | 4.15 × 10−6 | 1.24 | 1.23 × 10−4 |
| ENSG00000104312 | RIPK2 | receptor interacting serine/threonine kinase 2 | 1.33 | 1.43 × 10−6 | 1.22 | 9.05 × 10−6 |
| ENSG00000172602 | RND1 | Rho family GTPase 1 | 2.90 | 3.68 × 10−9 | 2.78 | 1.40 × 10−8 |
| ENSG00000007908 | SELE | selectin E | 3.31 | 1.92 × 10−3 | 3.21 | 3.67 × 10−3 |
| ENSG00000145365 | TIFA | TRAF interacting protein with forkhead associated domain | 1.84 | 8.22 × 10−7 | 1.82 | 1.51 × 10−6 |
| ENSG00000133069 | TMCC2 | transmembrane and coiled-coil domain family 2 | 1.91 | 1.75 × 10−4 | 2.00 | 1.21 × 10−4 |
| ENSG00000232810 | TNF | tumor necrosis factor | 5.92 | 3.92 × 10−5 | 4.79 | 1.16 × 10−3 |
| ENSG00000185215 | TNFAIP2 | TNF alpha induced protein 2 | 1.92 | 2.00 × 10−4 | 1.36 | 1.29 × 10−2 |
| ENSG00000118503 | TNFAIP3 | TNF alpha induced protein 3 | 4.91 | 4.96 × 10−9 | 4.41 | 3.14 × 10−8 |
| ENSG00000050730 | TNIP3 | TNFAIP3 interacting protein 3 | 1.85 | 1.37 × 10−3 | 1.53 | 1.72 × 10−2 |
| ENSG00000056558 | TRAF1 | TNF receptor associated factor 1 | 2.48 | 7.32 × 10−4 | 2.07 | 6.07 × 10−3 |
| ENSG00000173334 | TRIB1 | tribbles pseudokinase 1 | 1.22 | 5.86 × 10−3 | 1.05 | 3.28 × 10−2 |
| ENSG00000163874 | ZC3H12A | zinc finger CCCH-type containing 12A | 2.33 | 8.22 × 10−7 | 1.94 | 1.89 × 10−5 |
| ENSG00000128016 | ZFP36 | ZFP36 ring finger protein | 2.73 | 2.02 × 10−6 | 2.51 | 9.42 × 10−6 |