Table 1.
An overview of key features of each class 2 CRISPR system.
| Features | Type | |||
|---|---|---|---|---|
| Cas9 | Cas12a | Cas13a | Cas14 | |
| PAM | NGG | TTTN | - | - |
| Target | dsDNA | (ds/ss)DNA | ssRNA | ssDNA |
| Trans-cleavage | No | Yes | Yes | Yes |
| Trans-cleavage substrates | - | ssDNA | ssRNA | ssDNA |
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