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Effect of MA on topoisomerase I of S. aureus. Note: Form II (open circular DNA and linear); Form I (supercoiled DNA); a: pET-28a; b: topoisomerase; c: DMSO; d–j: 0.156 mg/mL; 0.3125 mg/mL; 0.625 mg/mL; 1.25 mg/mL; 2.5 mg/mL; 5 mg/mL; 10 mg/mL.
