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Nanoparticle-based multimodality PET imaging. (A) The broad range of targeted ligands that may be conjugated to CLIO, including, but not limited, to 18F through click chemistry and peptides. Tumor-bearing mice were coinjected with a fluorescent peptide against integrins, a fluorescent cathepsin sensor, and 64Cu-CLIO-VT680, and then subjected to in vivo multichannel PET-CT (B) and FMT/PET-CT (C) [163].
