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Exercise modulates bone marrow hematopoiesis. Physical exercise decreases hematopoietic stem and progenitor cell (HSPC) proliferation by inducing quiescence-promoting niche factors. Specifically, exercise decreases the production of adipose tissue-derived leptin and induces the expression of quiescence and retention factors in leptin receptor-positive stromal bone marrow cells (Lepr+ perivascular cells).
