Table 5.
Kinetic Model | Parameter | Sample 10/90/2 | Sample 10/90/3 |
---|---|---|---|
Higuchi ๐น = ๐๐ปโ๐ก1/2 |
kH | 9.218 | 3.350 |
R2 | โ0.918 | โ1.147 | |
AIC | 97.98 | 74.811 | |
KorsmeyerโPeppas ๐น = ๐๐พ๐โ๐ก๐ |
kKP | 33.247 | 12.499 |
n | 0.074 | 0.063 | |
R2 | 0.984 | 0.996 | |
AIC | 41.036 | โ2.927 | |
BakerโLonsdale 3/2[1โ(1โ๐น/100)2/3]โ๐น/100 =๐ ๐ต๐ฟโ๐ก |
kBL | 0.002 | 0 |
R2 | โ0.636 | โ1.054 | |
AIC | 96.078 | 74.27 |
kH: the constant of release at Higuchi model; R2: coefficient of determination; AIC: Akaikโs information criterion; F: the fraction of released drug in function of time t; kKP: the constant of release at Korsmeyer-Peppes model that takes into account structural and geometrical characteristics of dosage form; n: the exponent of release/diffusion; kBL: combined constant of release at Baker-Lonsdale model; [60,61,62].