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. 2023 Feb 9;24(4):3525. doi: 10.3390/ijms24043525
ADE: adverse drug effect
AFS: aryl-fluorosulfate (aryl-OSO2F)
bioTCI: biomolecular targeted covalent inhibitor
CD: cluster of differentiation
CHO: Chinese hamster ovary
CS: complimentary strand
CuAAC: copper(I)-catalyzed azide-alkyne cycloaddition
Da: Dalton
DS: double strand
EdUTP: 5-ethynyl-dUTP
EGFR: epidermal growth factor receptor
ELISA: enzyme-linked immunosorbent assay
Fab: fragment antigen binding (variable)
FasL: Fas ligand (CD95L, CD178)
Fc: fragment crystallizable (constant)
FcR: Fc receptor
FDA: Food and Drug Administration (USA
GPCR: G-protein-coupled receptor
HER2: human epidermal growth factor 2
mAb: monoclonal antibody
NK: natural killer
NGS: next-generation sequencing
OctdU: octadiynyl-dU
PCR: polymerase chain reaction
PD1: programmed cell death protein 1 (CD279)
PD-L1: programmed death-ligand 1 (CD274)
PK: pharmacokinetic
PPI: protein-protein interaction
PS: phosphorothioate
RBD: receptor binding domain
SARS-CoV-2: severe acute respiratory syndrome-associated coronavirus-2
SELEX: Systematic Evolution of Ligands by EXponential enrichment
SN2: bimolecular nucleophilic substitution
SNAr: nucleophilic aromatic substitution
SuFEx: sulfur (VI) fluoride exchange
SDS: sodium dodecyl sulfate
TBA: thrombin binding aptamer
TCI: targeted covalent inhibitor
TeTCI: tethered targeted covalent inhibitor
TRAIL: TNF-related apoptosis-inducing ligand
Uaa: unnatural amino acid