Table 1.

Clinical features of cases describing EGPA and GPA overlap syndrome

Case	Sex/age	GPA	EGPA	ANCA	Treatment	Outcome
Henochowichz 1986 [20]	25 F	Arthralgia, pulmonary nodules, purpuric lesions	Rhinitis, renal biopsy-proved necrotizing glomerulonephritis, eosinophilic vasculitis, renal and nose tissue eosinophilia	N/A	CCs, CYC	Remission
Krupsky 1993 [21]	43 M	Pulmonary nodules	Marked eosinophilia in the peripheral blood, pleural effusion	c-ANCA	CCs, CYC	Remission
Potter 1999 Case 1 [22]	M 29	Nasal ulcerations, alveolar hemorrhage	Sinus congestion, peripheral eosinophilia, eosinophilic vasculitis	PR3 +	CCs, MTX, trimethoprim/sulfamethoxazole	Remission
Potter 1999 Case 2 [22]	F 30	Alveolar hemorrhage	Peripheral eosinophilia, perivascular eosinophilic inflammatory infiltrates, sinus congestion	PR3 +	CCs, MTX, trimethoprim/sulfamethoxazole	Remission
Lane 2002 Case 1 [23]	N/A	Crusting, Nasal obstruction, sinusitis, lung infiltrates	Renal biopsy proved eosinophilic infiltrate	c-ANCA	N/A	N/A
Lane 2002 Case 2 [23]	N/A	Crusting, Nasal obstruction, deafness, bloody nasal discharge	Renal biopsy proved eosinophilic infiltrate	c-ANCA, PR3 +	N/A	N/A
Lane 2002 Case 3 [23]	N/A	Lung infiltrates	Peripheral eosinophilia, renal biopsy proved eosinophilic infiltrate	c-ANCA	N/A	N/A
Lane 2002 Case 4 [23]	N/A	Pulmonary nodules	Peripheral eosinophilia, Renal biopsy proved eosinophilic infiltrate	c-ANCA, PR3 +	N/A	N/A
Lane 2002 Case 5 [23]	N/A	Lung infiltrates	Renal biopsy proved eosinophilic infiltrate	c-ANCA	N/A	N/A
Shoda 2005 [24]	F 25	Pulmonary hemorrhage, suprascleritis; granulomatous inflammation of the nasal mucosa	Paranasal sinus abnormality, eosinophilia in the blood and around the blood vessels in the biopsy samples; elevated IgE levels	PR3 +	CCs, MTX, CYC	Remission
Uematsu 2014 [25]	F 78	Nasal obstruction with epistaxis; focal panarteritis with necrotizing vasculitis and histiocytic proliferation without eosinophilic infiltration at skin biopsy, microhaematuria	Peripheral eosinophilia, asthma	PR3 +	CCs, CYC	Remission
Surendran 2017 [26]	F 45	Rapidly progressive renale failure, Proptosis of right eye, saddle nose deformity; diffuse alveolar hemorrhage	Asthma; renal biopsy proved eosinophilic infiltrate	PR3 +	CCs, CYC	Remission
Quan 2018 [27]	F 50	Cavitary pulmonary lesions	Peripheral neuropathy; long-standing asthma; chronic sinusitis; peripheral eosinophilia; elevated IgE levels, eosinophilic infiltration in the pulmonary parenchyma	neg	Anti-IL-5 AZA CCs	Remission

N/A not available, MTX methotrexate, CCs steroids, CYC cyclophosphamide, AZA azathioprine