Table 4.

Multivariable Cox models of OS in relation to time to AT from SEER-Medicare and NCDB^a,b.

Predictors	Biopsy (N = 1232)			Resection (N = 1927)			Total (N = 3159)
	aHR	95%CI	P	aHR	95%CI	P	aHR	95%CI	P
SEER-Medicare, N = 3159a
Time to AT, days
≤ 15	1.00	–	–	1.00	–	–	1.00	–	–
16–26	1.03	0.88–1.20	0.706	0.90	0.78–1.02	0.105	0.97	0.87–1.07	0.496
27–37	1.04	0.89–1.23	0.608	0.74	0.64–0.84	< 0.001	0.86	0.78–0.96	0.005
≥ 38	0.86	0.73–1.01	0.068	0.81	0.71–0.92	0.002	0.86	0.78–0.95	0.004
Time to AT, cutoff as 27 days
< 27	1.00	–	–	1.00	–	–	1.00	–	–
≥ 27	0.93	0.83–1.05	0.225	0.82	0.74–0.90	< 0.001	0.88	0.82–0.94	< 0.001

Predictors	Biopsy (N = 1316)			Resection (N = 6845)			Total (N = 8161)
	aHR	95%CI	P	aHR	95%CI	P	aHR	95%CI	P
NCDB, N = 8161b
Time to AT, days
≤ 15	1.00	–	–	1.00	–	–	1.00	–	–
16–26	0.95	0.75–1.20	0.676	0.95	0.84–1.06	0.350	0.95	0.85–1.05	0.321
27–37	0.85	0.68–1.06	0.153	0.83	0.74–0.93	0.001	0.83	0.75–0.92	< 0.001
≥ 38	0.77	0.61–0.97	0.024	0.87	0.77–0.98	0.017	0.85	0.77–0.94	0.002
Time to AT, cutoff as 27 days
< 27	1.00	–	–	1.00	–	–	1.00	–	–
≥ 27	0.84	0.74–0.95	0.006	0.89	0.84–0.94	< 0.001	0.88	0.83–0.93	< 0.001

AT adjuvant therapy, HR hazard ratio, 95% CI 95% confidence interval.

^aAdjusted time to AT, age at diagnosis, gender, period, race/ethnicity, marital status, residence, education, income, registry location, surgery, AT, and Charlson Comorbidity Score by using multivariable Cox proportional models in SEER-Medicare.

^bAdjusted time to AT, age at diagnosis, gender, period, race/ethnicity, residence, education, income, insurance, facility location, distance, care transition, surgery, AT, and Charlson/Deyo score by using multivariable Cox proportional models in NCDB.