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. 2023 Feb 25;13:3280. doi: 10.1038/s41598-023-30464-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Results of immunohistochemistry. Immunostaining for AKR1C3 and loricrin was performed on formalin-fixed paraffin-embedded tissues of psoriasis lesions from 62 patients. (A) AKR1C3 expression in the epidermis was significantly lower in psoriasis lesional skin samples from patients with rs12529 G > C and rs12387 A > G than in patients with rs12529 G/G and rs12387 A/A (p = 0.0434, Student’s t-test). (B) Wide loricrin expression due to abnormal early expression was observed in the epidermis from patients with rs12529 G > C and rs12387 A > G SNPs. (C) AHR expression did not differ depending on the variant. (D) Representative immunostaining images of AKR1C3 (red) and loricrin (green) staining. (E) Ectopic expression of loricrin in the spinous layer in patients with the rs12529 G > C SNP.