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. 2023 Feb 25;12(1):9. doi: 10.1038/s41389-023-00457-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — EGFR acts as a phosphokinase of PELI1 to promote its phosphorylation, leading to the E3 ubiquitin ligase activation. Simultaneously, PELI1 enhanced the stability of EGFR via the K63-linked polyubiquitination. Compound S62 as a small molecule disruptor of PELI1/EGFR repressed breast cancer metastasis.