Table 3.

Replicated risk-markers-metabolites association for CRP, diastolic blood pressure, and systolic blood pressure.

Metabolite	Sex	Bio specimen	Super pathway	Sub pathway	β	95% CI	p-value	p-value (FDR)
Clinical biomarker: CRP
Betaine	Female	Blood	Amino acid	Glycine, serine and threonine metabolism	− 0.40	− 0.61 to − 0.19	0.0002	0.0220
Glutamine	Male	Urine	Amino acid	Glutamate metabolism	− 0.39	− 0.63 to − 0.15	0.0022	0.1008
Isoleucine	Male	Urine	Amino acid	Leucine, isoleucine and valine metabolism	− 0.29	− 0.53 to − 0.04	0.0218	0.2060
Tryptophan	Male	Urine	Amino acid	Tryptophan metabolism	− 0.38	− 0.63 to − 0.13	0.0033	0.1137
Clinical biomarker: diastolic blood pressure
Glutamine	Male	Blood	Amino acid	Glutamate metabolism	0.25	0.02–0.48	0.0337	0.2682
Clinical biomarker: systolic blood pressure
4-Hydroxyhippurate	Female	Urine	Xenobiotics	Benzoate metabolism	0.28	0.08–0.48	0.0072	0.1374
Androsterone sulfate	Female	Blood	Lipid	Androgenic steroids	− 0.17	− 0.35 to − 0.00	0.0496	0.3076
Glutamine	Female	Blood	Amino Acid	Glutamate metabolism	− 0.24	− 0.41 to − 0.07	0.0064	0.1368
Phenylalanine	Female	Urine	Amino Acid	Phenylalanine metabolism	0.19	0.00–0.38	0.0477	0.3076
	Male	Blood			0.25	0.02–0.48	0.0328	0.2682
Tryptophan	Female	Urine	Amino Acid	Tryptophan metabolism	0.19	0.00–0.38	0.0466	0.3076

Estimates are generated from linear regression. Models were adjusted for age and BMI, both at sample collection. Metabolites were log-transformed prior to analysis. Estimates and 95% CI are on the log scale.

We controlled the false discovery rate (FDR) at 5% to account for multiple testing. Metabolites significant after correction for multiple testing are marked in italics.