Table 4.
Metabolites mediating the association of body composition and habitual food intake with clinical biomarkers.
| Bio specimen | Sex | Clinical biomarker | Mediating metabolite | Total effect | ACME | ||||
|---|---|---|---|---|---|---|---|---|---|
| Estimate | 95% CI | p-value1 | Estimate | 95% CI | p-value1 | ||||
| Exposure: BMI | |||||||||
| Urine | Male | CRP | 5-Dodecenoylcarnitine (C12:1) | 0.51 | 0.254–0.747 | 0.000 | − 0.03 | − 0.134 to 0.035 | 0.983 |
| Exposure: body fat (%) | |||||||||
| Urine | Male | Leptin | Glucuronide of C10H18O2 (12)* | 0.62 | 0.203–1.040 | 0.040 | − 0.10 | − 0.285 to 0.018 | 0.983 |
Estimates and confidence intervals are in standard deviations.
ACME average causal mediation effect, CRP C-reactive Protein.
1p-values are corrected for multiple testing by holding the false discovery rate at 5%.