Fig. 6. Model diagram to indicate regulation of lncRNA-derived antigen presentation by E2F1 and PRMT5.

It is proposed that PRMT5 enzyme activity and E2F1 transcriptional activity influences the expression of many lncRNAs, which are subsequently translated into polypeptides that can be processed to generate epitopes for presentation on MHC class I protein complexes. Pharmacological manipulation of PRMT5 activity with compound T1-44 results in altered expression of several lncRNA transcripts encoding immunogenic peptides. We propose that subsequent presentation of these immunogenic peptides by MHC class I complexes contributes to the increased immune cell infiltration of the tumour micro-environment observed.