Table 2.

Inflammatory Conditions in Which Metal Allergy May Indirectly Contribute to Disease Pathogenesis.

Tissue	Disease
Dermal	Rosacea
Responses	Psoriasis
Respiratory	Pulmonary Alveolar Proteinosis
Responses	Goodpasture’s Syndrome
GI	Celiac Disease
Responses	Gastro-Esophageal Reflux Disease Irritable Bowel Syndrome Ulcerative Colitis
Systemic Responses	Systemic Lupus Erythematosus Rheumatoid Arthritis Chronic Fatigue Syndrome Sjogren’s Syndrome Goodpasture’s Syndrome Fibromyalgia Panniculitis Cutaneous T-Cell Lymphomas

Table 2: A list of inflammatory conditions in which metal allergy may contribute to disease pathogenesis. In addition to the primary presentations of metal allergy listed in Table 1, allergic responsivity to sensitizing metals has also been indirectly associated with several other disease states. These conditions are listed in the table above, in accordance with the tissue/anatomical compartment of relevance. Although it remains largely unclear what role metal allergy plays in the pathogenesis of these disorders, ample evidence exists within the scientific literature to suggest that, in some cases, metal allergy can promote the development, progression, and severity of symptomology in these disease states.