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Type and Level of Experimental Parameters and the Critical Quality Attribute Used in 2k Factorial Design
| Independent Variables | Level | |
|---|---|---|
| Low | High | |
| BM concentration, % (w/v), (X1) | 2 | 7 |
| Surfactant concentration, % (w/v), (X2) | 5 | 10 |
| Homogenization speed, rpm (X3) | 11,000 | 16,000 |
| Homogenization time, min (X4) | 1 | 3 |
| Sonication amplitude, % (X5) | 35 | 80 |
| Sonication time, min (X6) | 1 | 5 |
| Dependent variables | Constraints | |
| PS, nm (Y1) | Minimize | |
| PDI, (Y2) | Minimize | |
