Table 4.
Proposed Experiments by 2k Factorial Design and Their Responses for 16 Formulations of Nanostructured Lipid Carriers
| Run | Experimental Factors | Dependent Variables | ||||||
|---|---|---|---|---|---|---|---|---|
| Formulation | X1 | X2 | X3 | X4 | X5 | X6 | Y1 | Y2 |
| FD1 | 2 | 10 | 16000 | 3 | 35 | 5 | 46.77 | 0.262 |
| FD2 | 2 | 10 | 11000 | 1 | 80 | 5 | 44.77 | 0.278 |
| FD3 | 2 | 10 | 16000 | 1 | 35 | 1 | 117.57 | 0.496 |
| FD4 | 2 | 5 | 11000 | 3 | 35 | 5 | 126.33 | 0.441 |
| FD5 | 2 | 10 | 11000 | 3 | 80 | 1 | 58.86 | 0.242 |
| FD6 | 7 | 10 | 16000 | 3 | 80 | 5 | 121.93 | 0.270 |
| FD7 | 7 | 5 | 11000 | 3 | 80 | 5 | 119.20 | 0.227 |
| FD8 | 2 | 5 | 16000 | 3 | 80 | 1 | 178.33 | 0.429 |
| FD9 | 2 | 5 | 11000 | 1 | 35 | 1 | 207.67 | 0.430 |
| FD10 | 7 | 10 | 11000 | 1 | 35 | 5 | 115.50 | 0.439 |
| FD11 | 7 | 10 | 16000 | 1 | 80 | 1 | 184.07 | 0.504 |
| FD12 | 7 | 5 | 16000 | 1 | 35 | 5 | 137.53 | 0.248 |
| FD13 | 7 | 5 | 11000 | 1 | 80 | 1 | 152.83 | 0.256 |
| FD14 | 2 | 5 | 16000 | 1 | 80 | 5 | 93.04 | 0.229 |
| FD15 | 7 | 5 | 16000 | 3 | 35 | 1 | 144.13 | 0.259 |
| FD16 | 7 | 10 | 11000 | 3 | 35 | 1 | 186.73 | 0.412 |
Abbreviations: X1, Binary mixture concentration (% w/v); X2, Surfactant concentration (% w/v); X3, Homogenization speed (rpm); X4, Homogenization time (min); X5, Sonication amplitude (%); X6, Sonication time (min); Y1, PS (nm); Y2, Polydispersity Index.