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. Author manuscript; available in PMC: 2023 Jun 9.
Published in final edited form as: Science. 2022 Dec 8;378(6624):1111–1118. doi: 10.1126/science.abq2787

Fig. 1. Ongoing positive selection in the global Mtb population.

Fig. 1.

(A) Diagram of fixed and unfixed variants. (B) Genes and IGRs with signal of ongoing positive selection. Known drug-resistance (DR) or drug-tolerance (DT) genes are marked with capsule symbols. Red stars indicate transcriptional regulators. The map shows the geographic origin of the clinical Mtb isolates and their DR status; DT (drug-tolerance), MDR (multi-drug resistance). (C) Categories of genes under positive selection, with adjusted P values for enrichment. (D) dN/dS ratio of resR in DR and DS strains, P value by unpaired t test. (E) Structural model of the ResR dimer (cyan, predicted by Alphafold) aligned to MerR-family homolog CueR (orange) (49) in complex with duplex DNA with common ResR clinical mutations indicated (yellow). (F) Schematic of construction of mutations in the chromosomal copy of resR in Mtb.