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. Author manuscript; available in PMC: 2023 Feb 26.
Published in final edited form as: Chem Res Toxicol. 2020 May 19;33(7):1729–1735. doi: 10.1021/acs.chemrestox.0c00008

Table 2.

Special Circumstances Allowing (αfb)water (1:10) ≈ (αfb)e-liquida

case 1 no protonating acid is present in the e-liquid, so (αfb)e-liquid = 1, and the nicotine concentration after dilution is high enough to yield a relatively high aqueous pH, giving (αfb)water (1:10) ≈ 1
case 2 a protonating acid is present in the e-liquid and is sufficiently strong to react stoichiometrically with free-base nicotine in both the e-liquid and in water
2a (eq/L acid/eq/L nicotine) = y < 1: (αfb)e-liquid ≈ (αfb)water (1:10) ≈ 1 − y
2b (eq/L acid/eq/L nicotine) ≥ 1: (αfb)e-liquid ≈ (αfb)water (1:10) ≈ 0
a

Assumes the use of CO2-free water.