Table 2.

Studies Using Glycosides to Solubilise Poorly Water-Soluble Drugs

Glycoside	Molecular Weight	CMC (mg/mL)	Active Ingredients to Glycoside Ratio (w/w)	Micelle Size (nm)	Solubility (mg/mL)	Enhancement Ratio of Solubilitya	Enhancement Ratio of AUCa	Reference
Hesperidin-G	772.7	5.0	Naringenin: Hesperidin-G =1:20	-	3.5± 0.2	77	-	[41]
			Flurbiprofen: Hesperidin-G =1:10	-	0.5	10	2.8	[42]
			Probucol: Hesperidin-G =1:10	-	0.005	1000	5.3	[43]
			Glibenclamide: Hesperidin-G =1: 5	-	-	-	6	[44]
			Naringenin: Hesperidin-G =1:10	-	1.4	30	-	[16]
Rutin-G	759	5.0	Tranilast: Rutin-G=1:10	2.9	0.04	32.2	36.4	[45]
			Ipriflavone: Rutin-G=1:10	-	0.003	3	4.3	[46]
			Folic acid: Rutin-G= 1:2	<100	1	100	-	[47]
			Flurbiprofen: Rutin-G =1:10	-	-	-	2.2	[17]
Stevia-G	965.0	12	Propolis: Stevia-G =1:10	350	-	-	6.4	[48]
			Curcumin: Stevia-G=1:10	-	0.5	1600	-	[29]
			Curcumin: Stevia-G: PVP K-30=1:10:0.5	-	4.1	13,000	6.7	[29]
			Indomethacin: Stevia-G=1:10	-	0.04	5	-	[49]
			Flurbiprofen: Stevia-G=1:10	-	0.06	1.6	2.2	[43]
			Probucol: Stevia-G=1:10	-	0.007	1340	9.8	[43]
			Mefenamic acid: Stevia-G: LTAC=1:10:1	-	-	-	-	[50]
			Naringenin: Stevia-G=1:10	3	1.8	36	-	[18]
			Quercetin: Stevia-G: PVP =1:10:5	-	0.1	5	-	[51]
Stevioside	804.9	4.9	-	4.7	1.0	45	-	[52]
Rebaudioside A	967.0	-	Naringenin: Rebaudioside A=1:24	5.2	24.6	2198	2.1	[53]
Mogroside V	1287.4	5.5	Silybin: Mog-V =1:20	206	2.2	1931	24.5	[19]
			Curcumin: Mog-V=1:10	154	1.4	5712	29	-
ssβ-glucan	-	-	Quercetin: ssβ-glucan=1:10	-	-	-	-	[54]
Naringin-G	742.5	-	Pranlukast hemihydrate: Naringin-G =1:5	2.7	-	-	2.2	[55]
Rubusoside	642.7	-	Curcumin: Rubusoside=1:20	8	2.3	2318	-	[20]

Note: ^aAfter Solubilisation /Untreated Drug.

Abbreviations: PVP, Polyvinylpyrrolidone; Hesperidin-G, α-Glucosyl Hesperidin; Rutin-G, α-Glycosyl Rutin; Stevia-G, α-Glucosyl Stevia; Naringin-G, α-Glycosylated Naringin; LTAC, Lauryl Trimethyl Ammonium Chloride.