TABLE 3.

Univariate and multivariate Cox regression analysis for DFS of part‐solid NSCLC patients (optimal cutoff)

Characteristics	DFS: Total tumor size cutoff 2.4 cm			Characteristics	DFS: Solid component size cutoff 1.4 cm
	Univariate HR (95% CI)	Multivariate HR (95% CI)	p‐value		Univariate HR (95% CI)	Multivariate HR (95% CI)	p‐value
Age	1.06 (1.02–1.11)	1.05 (1.01–1.10)	0.018	Age	1.06 (1.02–1.11)	1.05 (1.01–1.1)	0.025
Gender (female)	0.46 (0.20–1.07)	0.46 (0.17–1.28)	0.135	Gender (Female)	0.46 (0.20–1.07)	0.56 (0.21–1.54)	0.265
Smoking	2.34 (0.92–6.00)	1.42 (0.45–4.45)	0.551	Smoking	2.34 (0.92–6.00)	1.48 (0.48–4.58)	0.492
CTR (cont. var.)	5.36 (0.76–37.87)	32.39 (0.42–51.93)	0.117	CTR (cont. var.)	5.36 (0.76–37.87)	1.48 (0.08–27.1)	0.792
Total tumor size				Total tumor size	2.87 (1.33–6.23)	1.42 (0.47–4.26)	0.535
≤2.40 cm	1.00	1.00	/	Solid component size
2.40 ~ 3.0 cm	5.05 (2.17–11.74)	6.21 (1.58–24.34)	0.009	≤1.40 cm	1.00	1.00	/
Solid component size	2.61 (1.32–5.16)	0.29 (0.05–1.83)	0.186	1.40 ~ 3.0 cm	3.51 (1.48–8.29)	2.27 (1.04–5.92)	0.045
Surgical procedures			0.995	Surgical procedures			0.993
Segmentectomy	1.00	1.00	/	Segmentectomy	1.00	1.00	/
Wedge resection	2.27 (0.48–10.71)	0.92 (0.18–4.81)	0.922	Wedge resection	2.27 (0.48–10.71)	1.11 (0.21–5.82)	0.905
Lobectomy	1.67 (0.68–4.09)	0.98 (0.37–2.62)	0.969	Lobectomy	1.67 (0.68–4.09)	1.03 (0.39–2.76)	0.950
MIA vs. IAC	0.32 (0.04–2.37)	0.68 (0.08–5.64)	0.720	MIA vs. IAC	0.32 (0.04–2.37)	0.69 (0.08–6.00)	0.739
N1‐2 vs. N0	6.06 (1.71–21.5)	3.72 (1.04–14.97)	0.038	N1‐2 vs. N0	6.06 (1.71–21.5)	3.53 (1.06–14.54)	0.036

Note: p < 0.05 was marked in bold.

Abbreviations: CTR, consolidation‐to‐tumor ratio; DFS, disease‐free survival; IAC, invasive adenocarcinoma; MIA, minimally invasive adenocarcinoma; NSCLC, non‐small cell lung cancer.