Table A3.
Chlorogenic acid-regulated KEGG pathways.
| #term ID | term description | DGC | BGC | strength | FDR | matching proteins in network (labels) |
|---|---|---|---|---|---|---|
| hsa05202 | Transcriptional misregulation in cancer | 6 | 169 | 1.76 | 3.93E-08 | PLAT, RARA, MDM2, FLT1, CD14, PLAU |
| hsa05203 | Viral carcinogenesis | 4 | 183 | 1.55 | 0.00018 | MDM2, RAC1, CASP8, CHEK1 |
| hsa04115 | p53 signaling pathway | 3 | 68 | 1.86 | 0.00028 | MDM2, CASP8, CHEK1 |
| hsa05200 | Pathways in cancer | 5 | 515 | 1.2 | 0.00028 | HMOX1, RARA, MDM2, RAC1, CASP8 |
| hsa04620 | Toll-like receptor signaling pathway | 3 | 102 | 1.68 | 0.00052 | CD14, RAC1, CASP8 |
| hsa05215 | Prostate cancer | 3 | 97 | 1.7 | 0.00052 | PLAT, MDM2, PLAU |
| hsa05418 | Fluid shear stress and atherosclerosis | 3 | 133 | 1.57 | 0.00094 | HMOX1, PLAT, RAC1 |
| hsa05206 | MicroRNAs in cancer | 3 | 149 | 1.52 | 0.0011 | HMOX1, MDM2, PLAU |
| hsa05205 | Proteoglycans in cancer | 3 | 195 | 1.4 | 0.0022 | MDM2, RAC1, PLAU |
| hsa05134 | Legionellosis | 2 | 54 | 1.78 | 0.0049 | CD14, CASP8 |
| hsa05416 | Viral myocarditis | 2 | 56 | 1.77 | 0.0049 | RAC1, CASP8 |
| hsa04010 | MAPK signaling pathway | 3 | 293 | 1.22 | 0.0054 | FLT1, CD14, RAC1 |
| hsa05221 | Acute myeloid leukemia | 2 | 66 | 1.69 | 0.0056 | RARA, CD14 |
| hsa01524 | Platinum drug resistance | 2 | 70 | 1.67 | 0.0058 | MDM2, CASP8 |
| hsa04151 | PI3K-Akt signaling pathway | 3 | 348 | 1.15 | 0.0067 | MDM2, FLT1, RAC1 |
| hsa04610 | Complement and coagulation cascades | 2 | 78 | 1.62 | 0.0067 | PLAT, PLAU |
| hsa05132 | Salmonella infection | 2 | 84 | 1.59 | 0.0068 | CD14, RAC1 |
| hsa04064 | NF-kappa B signaling pathway | 2 | 93 | 1.54 | 0.0079 | CD14, PLAU |
| hsa04066 | HIF-1 signaling pathway | 2 | 98 | 1.52 | 0.0082 | HMOX1, FLT1 |
| hsa04110 | Cell cycle | 2 | 123 | 1.42 | 0.0122 | MDM2, CHEK1 |
| hsa04145 | Phagosome | 2 | 145 | 1.35 | 0.0159 | CD14, RAC1 |
| hsa04932 | Non-alcoholic fatty liver disease (NAFLD) | 2 | 149 | 1.34 | 0.016 | RAC1, CASP8 |
| hsa04218 | Cellular senescence | 2 | 156 | 1.32 | 0.0167 | MDM2, CHEK1 |
| hsa05152 | Tuberculosis | 2 | 172 | 1.28 | 0.0194 | CD14, CASP8 |
| hsa05167 | Kaposi's sarcoma-associated herpesvirus infection | 2 | 183 | 1.25 | 0.0209 | RAC1, CASP8 |
| hsa04510 | Focal adhesion | 2 | 197 | 1.22 | 0.0232 | FLT1, RAC1 |
| hsa04015 | Rap1 signaling pathway | 2 | 203 | 1.21 | 0.0236 | FLT1, RAC1 |
| hsa04810 | Regulation of actin cytoskeleton | 2 | 205 | 1.2 | 0.0236 | CD14, RAC1 |
| hsa04014 | Ras signaling pathway | 2 | 228 | 1.16 | 0.0275 | FLT1, RAC1 |
| hsa05165 | Human papillomavirus infection | 2 | 317 | 1.01 | 0.0497 | MDM2, CASP8 |