Table 3.
Neutralising titres of serum elicited in rabbits prime boost vaccinated (days 0 and 21) with plant-produced SARS-CoV-2 Beta VLPs and formulated with three different adjuvants namely SEPIVAC SWE, Afrigen “AS IS” or DCA slow release. ID50 values are the inhibitory dilutions at which 50% neutralisation is attained. A value < 50 is indicated as 0.
| Beta VLP vaccinated rabbits |
||||||||
|---|---|---|---|---|---|---|---|---|
| Days |
||||||||
| Adjuvants | Rabbit no. | 7 | 14 | 21 | 28 | 35 | 42 | |
| SEPIVAC SWE | M1 | 294 | 76 | 110 | 1870 | 2635 | 436 | |
| M2 | 0 | 0 | 0 | 3022 | 5804 | 402 | ||
| M3 | 0 | 0 | 0 | 2049 | 7585 | 160 | ||
| GMT | 98 ± 170 | 25 ± 44 | 36 ± 64 | 2313 ± 620 | 5341 ± 2507 | 332 ± 151 | ||
| Afrigen “AS IS” | M5 | 0 | 99 | 51 | 1333 | 0 | 579 | |
| M6 | 0 | 0 | 0 | 453 | 285 | 99 | ||
| M7 | 0 | 0 | 0 | 218 | 147 | 0 | ||
| GMT | 33 ± 57 | 17 ± 29 | 668 ± 588 | 144 ± 143 | 226 ± 310 | |||
| DCA slow release | M9* | 643 | 97 | |||||
| M10 | 0 | 0 | 0 | 126 | 95 | 0 | ||
| M11 | 0 | 0 | 0 | 991 | 478 | 226 | ||
| GMT | 214 ± 371 | 32 ± 56 | 558 ± 612 | 287 ± 271 | 113 ± 160 | |||
* Cage injured animal euthanised after day 14.