Table 1.
Apparent Km and Vmax values and related transporter efficiencies (Vmax/Km) of OAT4-mediated cellular uptake of PFHpA, PFOA, PFNA, PFDA, PFHxS and PFOS obtained in the present study
| Apparent Km (µM) | Apparent Vmax (nmol min−1 mg protein−1) | Transporter efficiency (µL min−1 mg protein−1) | Reported albumin/water partition coefficients (L kg−1)a | Reported half-life in humans (years) | |
|---|---|---|---|---|---|
| Perfluoroalkyl carboxylic acids (PFCAs) | |||||
| PFHpA (C7) | 60 (15) | 4.5 (0.4) | 75 | 4.0 | 0.17b |
| PFOA (C8) | 47 (15) | 4.5 (0.5) | 96 | 4.2 | 1.8–3.8c |
| PFNA (C9) | 58 (15) | 8.5 (0.7) | 147 | 4.3 | |
| PFDA (C10) | 39 (15) | 6.0 (0.7) | 154 | 4.7 | |
| Perfluoroalkyl sulfonic acids (PFSAs) | |||||
| PFBS (C4) | NA | NA | NA | 3.2 | 0.07–0.12d |
| PFHxS (C6) | 92 (33) | 7.3 (1.0) | 79 | 4.8 | 2.9–8.5c |
| PFOS (C8) | 48 (24) | 2.2 (0.4) | 46 | 4.7 | 1.8–5.4c |
Data obtained from three studies (Fig. 4) were analysed using Graphpad Prism version 9.2.0 and are presented as best-fit values and standard errors between brackets. For comparison, reported albumin/water partition coefficients and half-lives in humans are also included
aTaken from Allendorf et al. (2019)
bFrom Xu et al. (2020)
cFrom Olsen et al. (2007), Li et al. (2018), and Xu et al. (2020)
dFrom Olsen et al. (2009)