Table 2.

Docking scores of PFASs and probe substrates of URAT1 and OAT4

Compound	OAT4		URAT1
	Score (kcal mol−1; mean ± standard deviation)a	Substrate	Score (kcal mol−1; mean ± standard deviation)a	Substrate
PFHpA	− 6.1 ± 0.0	Yes	− 5.5 ± 0.0	No
PFOA	− 6.2 ± 0.0	Yes	− 6.0 ± 0.0	No
PFNA	− 6.7 ± 0.2	Yes	− 6.6 ± 0.0	No
PFDA	− 7.1 ± 0.0	Yes	− 6.7 ± 0.0	No
PFHxS	− 6.4 ± 0.0	Yes	− 5.9 ± 0.1	No
PFOS	− 7.2 ± 0.2	Yes	− 6.9 ± 0.1	No
PFBS	− 5.5 ± 0.0	No	− 4.9 ± 0.0	No
Uric acid	–	–	− 6.6 ± 0.0	Yes
Prostaglandin E2	− 6.0 ± 0.0	Yes	–	–

^aThe scores are reported as means of three independent runs ± standard deviation