Table 4.

Receiver operating characteristics (ROC) curve analyses

		CPA1	CPA2	TAP	amylase	lipase	miR217
Correlated to pancreatic injury
2. A Sensitivity studies only. All time-points (103 control, 132 treated)	AUC	0.79	0.72	0.81	0.67	0.77	0.87
	sensitivity	64%	43%	69%	50%	50%	75%
	cut-off	N/A	N/A	2	1.3	1.3	N/A
2. B Sensitivity studies only ≤ 3 days (55 controls, 87 treated)	AUC	0.9	0.82	0.97	0.68	0.80	0.97
	sensitivity	86%	63%	90%	53%	57%	95%
	cut-off	N/A	N/A	2.2	1.4	0.3	N/A
2. C Sensitivity and specificity studies. All time-points. 2.A sample set with added specificity samples (40 controls and 68 treated)	AUC	0.78	0.72	0.80	0.63	0.75	0.87
	sensitivity	64 %	43%	70%	48%	46%	75%
	cut-off	N/A	N/A	2	1.4	1.5	N/A
Correlated to treatment with pancreatic toxicant, 4-6 hrs post-dose
2. D Sensitivity studies 4-6 hours post-dose with controls ≤ 3 days (57 controls, 37 treated)	AUC	0.90	0.88	0.89	0.86	0.95	0.81
	sensitivity	76%	76%	76%	76%	76%	59%
	cut-off	N/A	N/A	1.9	1.4	1.3	N/A