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. 2023 Feb 26;13:3300. doi: 10.1038/s41598-023-30453-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Simulation summary. Four administration schedules are compared in this simulation scenario: (1) 0.25 mg/kg every 24 h at 8 a.m.; (2) 0.25 mg/kg every 24 h at 8 p.m.; (3) 0.25 mg/kg twice a day at 8 a.m. and 8 p.m.; (4) 0.5 mg/kg twice a day at 8 a.m. and 8 p.m. 500 individuals were simulated for each scenario (for a total of 2500 individuals, with placebo). Curves are the median time-course of the molecule from this simulated population. Comparisons between schedules are made by calculating the percent difference between the median AUC and placebo (of each schedule). Summary results are tabulated in Table 2.