Figure 3.

Effect of persistent IL-1β exposure on the cell morphology of human OA chondrocytes. Human OA chondrocytes were incubated for 6 days with 0.1 ng/ml or without IL-1β. Data is representative of (A) area, (B) length, (C) width, (D) circularity, (E) aspect ratio, (F) roundness, and (G) solidity values obtained from individually measured chondrocytes with 11733 cells analyzed for the control group and 9058 cells analyzed for the IL-1β incubation group from n = 8 per group isolated from 8 different donors. Box plots: the boxes define the 25th and 75th percentiles, with a central line at the median; error bars define the 10th and 90th percentiles; and dots define the 5th and 95th percentiles.*p<0.05.