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Evaluation of cytokine and chemokine concentrations in melanoma patients during the ICI treatment. Levels of IL-6 (A), IL-8 (B), TNF-α (C) and CCL5 (D) were measured in plasma of metastatic patients responding (n=12) and non-responding (n=4) to the ICI therapy (point 0 - before the treatment; 1 - after the first injection; 2 - after the second injection; 3 - after the third injection) by bio-plex assay and expressed as pg/ml. *P < 0.05, **P < 0.01.
