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. 2023 Feb 13;14:1093038. doi: 10.3389/fphar.2023.1093038

FIGURE 2.

FIGURE 2

Natural products regulate mitochondrial fusion and fission. Mitochondrial fusion is mediated by MFN1, MFN2, and OPA1, while mitochondrial fission is mediated by DRP1, FIS1, and MFF. Natural products such as tetrahydrocurcumin, quercetin, and liquiritigenin regulate mitochondrial dynamics by modulating mitochondrial fusion and fission mediators.