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. 2023 Feb 13;11:1138702. doi: 10.3389/fbioe.2023.1138702

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Copyright © 2023 Chen, Xu and Champer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TADE drive inheritance and egg viability. Cross data are displayed for (A) the TADE suppression drive and (B) the 2-gRNA TADE drive. Drive inheritance and egg-to-adult viability was measured from crosses between drive individuals (heterozygous for the drive and for a Cas9 allele) and wild-type flies. Each dot represents offspring from one drive parent, and the size of dots is proportional to the number of total offspring for drive inheritance or the number of eggs for egg viability. Rate and standard error of the mean are displayed for all flies pooled together. No instances of drive inheritance are significantly different from the Mendelian expectation (Binomial Exact Test). *** indicates statistical significance of p < 0.0001 for egg viability compared to w ¹¹¹⁸ controls (Fisher’s Exact Test, see Supplementary Data Sets S1, S2).