TABLE 1.
Summary of the mechanism of ADSCs promoting wound healing. ADSCs are adipose-derived stem cells; TGF is transforming growth factor; IL is interleukin; TNF is tumor necrosis factor; Arg is arginase; PGE is prostaglandin; DC is dendritic cell; IFN is tumor necrosis factor; VEGF is Vascular endothelial growth factor; MCP is monocyte chemotactic protein; AT-Ex adipose tissue extracellular fraction.
| Different mechanisms of ADSCs promoting wound healing | Method | References |
|---|---|---|
| regulation of macrophages | Secretes TGF-β, IL-1β and IL-6 and increases macrophage recruitment | Deng et al. (2019) |
| Secretion of TNF, IL-10 | Stojanović and Najman (2019) | |
| Induced synthesis of Arg-1 | Sin et al. (2017) | |
| regulation of cellular immunity | Secretion of PGE-2 inhibits DC hypermaturity and attenuates T cell proliferation | Yañez et al. (2010) |
| Inhibit T cell differentiation and activation, reduce IFN-γ | Blazquez et al. (2014) | |
| Mediates anti-CD3, CD2, CD28 stimuli, inhibits T cell activation | Ren et al. (2019) | |
| angiogenesis | Secretion of VEGF, TGF-β, IL-6 | Lin et al. (2003) |
| Interacts with vascular endothelial cells and macrophages to increase MCP-1 and VEGF secretion | Bachmann et al. (2020) | |
| epithelialization Regulate the extracellular matrix | Recognizing the RGD sequence of the α5β1 protein receptor | Zang et al. (2019) |
| Enhances dermal and epidermal cell proliferation in a dose-dependent manner Upregulates the ratio of collagen type III to collagen type I | Bellei et al. (2018) | |
| Wang et al. (2019) |