Table 3.
Liver and Spleen Indices Following Treatment of Schistosoma mansoni (Egyptian Strain)-Infected Mice by SPL Free Drug, SPL-Loaded PLGA NPs (F4), and PZQ
| Group (n) | Spleen Index | Liver Index | ||||
|---|---|---|---|---|---|---|
| Mean ± (SD) | % of Reduction* | ANOVA (ρ value) | Mean± (SD) | % of Reduction* | ANOVA (ρ value) | |
| Infected non-treated control (4) | 2.06 (0.13) | 9.56 (0.27) | ||||
| Control solvent- administrated (4) | 1.99 (0.15) | 9.61 (0.22) | ||||
| SPL free drug (9) | 1.29 (0.40) | 37.38 | 0.001 | 7.62 (1.24) | 20.29 | 0.020 |
| SPL-loaded PLGA NPs (9) | 1.25 (0.28) | 39.32 | 0.001 | 7.43 (0.90) | 22.28 | 0.009 |
| PZQ (4) | 0.88 (0.00) | 57.28 | 0.000 | 7.01 (0.96) | 26.67 | 0.007 |
Notes: n: Number of euthanized mice, *Percentage of reduction is calculated as regards the infected untreated mice group as: (Mean of a parameter in the control group – mean of the parameter in the treated group) / Mean of parameter in the control group × 100.
Abbreviations: SPL, spironolactone; SPL-loaded PLGA NPs, spironolactone-loaded poly(lactic-co-glycolic acid) nanoparticles; PZQ, praziquantel.