Table 4.
Worm Burden Following Treatment of Schistosoma mansoni (Egyptian Strain)-Infected Mice by SPL Free Drug, SPL-Loaded PLGA NPs (F4), and PZQ
| Group (n) | Male Worm Mean ± (SD) | Female Worm Mean ± (SD) | % of Reduction* | ANOVA (ρ value) | Total Worm Mean ± (SD) | % of Reduction* | ANOVA (ρ value) |
|---|---|---|---|---|---|---|---|
| Infected Control (4) | 7 (1) | 6 (1) | 13 (0) | ||||
| Control Solvent (4) | 6 (1) | 6 (1) | 12 (1) | ||||
| SPL Free Drug (9) | 3 (1) | 4 (2) | 33.33 | 7 (3) | 46.15 | 0.003 | |
| SPL-loaded PLGA NPs (9) | 3 (2) | 2 (2) | 66.67 | 0.016 | 5 (3) | 61.54 | 0.000 |
| PZQ (4) | 4 (1) | 2 (1) | 66.67 | 0.011 | 5 (1) | 61.54 | 0.002 |
Notes: n: Number of euthanized mice, *Percentage of reduction is calculated as regards the infected untreated mice group as: (Mean of a parameter in the control group – mean of the parameter in the treated group) / Mean of parameter in the control group.
Abbreviations: SPL, spironolactone; SPL-loaded PLGA NPs, spironolactone-loaded poly(lactic-co-glycolic acid) nanoparticles; PZQ, praziquantel.