Table 5.
Tissue Egg Load Following Treatment by SPL Free Drug, SPL-Loaded PLGA NPs (F4), and PZQ of Schistosoma mansoni (Egyptian Strain)-Infected Mice
| Group (n) | Hepatic Egg Load MEAN ± (SD) | % Reduction* | ANOVA (ρ value) | Intestinal Egg Load Mean ± (SD) | % Reduction* | ANOVA (ρ value) |
|---|---|---|---|---|---|---|
| Infected Control (4) | 26.58 (3.79) | 16.8 (0.0) | ||||
| Control Solvent (4) | 20.67 (2.75) | 15.0 (0.7) | ||||
| SPL Free Drug (9) | 14.79 (4.84) | 44.36 | 0.000 | 8.6 (3.5) | 48.81 | 0.004 |
| SPL-loaded PLGA NPS (9) | 11.23 (3.84) | 57.75 | 0.000 | 7.7 (4.6) | 54.17 | 0.001 |
| PZQ (4) | 8.44 (0.55) | 68.25 | 0.000 | 6.0 (0.8) | 64.29 | 0.001 |
Notes: n: Number of euthanized mice, *Percentage of reduction is calculated as regards the infected untreated mice group as: (Mean of a parameter in the control group – mean of the parameter in the treated group) / Mean of parameter in the control group.
Abbreviations: SPL, spironolactone; SPL-loaded PLGA NPs, spironolactone-loaded poly(lactic-co-glycolic acid) nanoparticles; PZQ, praziquantel.