Table 6.
Oogram Patterns Following Treatment of Schistosoma mansoni (Egyptian Strain)-Infected Mice by SPL Free Drug, SPL-Loaded PLGA NPs, and PZQ
| Group (n) | Immature Egg% Mean ± (SD) | ANOVA (ρ value) | Mature Egg% Mean ± (SD) | Dead Egg % Mean ± (SD) | ANOVA (ρ value) |
|---|---|---|---|---|---|
| Infected Control (4) | 50 (4) | 29 (2) | 21 (3) | ||
| Solvent Control (4) | 56 (8) | 28 (11) | 17 (4) | ||
| SPL Free Drug (9) | 27 (5) | 0.000 | 24 (5) | 49 (6) | 0.000 |
| SPL-loaded PLGA NPs (9) | 28 (6) | 0.000 | 22 (7) | 50 (5) | 0.000 |
| PZQ (4) | 21 (2) | 0.000 | 20 (6) | 59 (9) | 0.000 |
Abbreviations: SPL, spironolactone; SPL-loaded PLGA NPs, spironolactone-loaded poly(lactic-co-glycolic acid) nanoparticles; PZQ, praziquantel.