Table 1.
Bidirectional Two-sample univariable Mendelian randomization analysis of the relationship between SLE and hyperthyroidism or hypothyroidism.
| Exposure | Outcome | Method | nSNP | OR | 95%CI | P-value |
|---|---|---|---|---|---|---|
| SLE | Hyperthyroidism | MRE-IVW | 38 | 1.045 | (0.987, 1.107) | 0.130 |
| SM | 1.040 | (0.950, 1.140) | 0.397 | |||
| WME | 1.025 | (0.935, 1.124) | 0.593 | |||
| MR-Egger | 1.134 | (0.994, 1.294) | 0.070 | |||
| SLE | Hypothyroidism | MRE-IVW | 37 | 1.049 | (1.020, 1.079) | <0.001 |
| SM | 1.052 | (1.024, 1.079) | <0.001 | |||
| WME | 1.031 | (1.007, 1.055) | 0.011 | |||
| MR-Egger | 1.075 | (1.011, 1.142) | 0.027 | |||
| Hyperthyroidism | SLE | MRE-IVW | 5 | 1.920 | (1.310, 2.814) | <0.001 |
| SM | 2.049 | (1.652, 2.542) | <0.001 | |||
| WME | 1.254 | (0.994, 1.582) | 0.056 | |||
| MR-Egger | 3.165 | (1.373, 7.298) | 0.074 | |||
| Hypothyroidism | SLE | MRE-IVW | 37 | 1.630 | (1.125, 2.362) | 0.010 |
| SM | 1.484 | (1.189, 1.851) | <0.001 | |||
| WME | 1.417 | (1.153, 1.741) | <0.001 | |||
| MR-Egger | 1.920 | (0.751, 4.908) | 0.182 |
SLE, systemic lupus erythematosus; SNP, single-nucleotide polymorphism; MRE-IVW, multiplicative random effects-inverse variance weighted; SM, simple mode; WME, weighted median.