Table 1.
Minimum inhibitory concentration MIC (mg/ml) and minimum bactericidal concentration MBC (mg/ml) values of FCs against different pathogens bacterial strains.
| Name of compound | R | c Log Pa | Escherichia coli (G−) | Pseudomonas aerugino (G−) | Staphylococcus aureus (G+) | Bacillus subtilis (G+) | |
|---|---|---|---|---|---|---|---|
| FA | H | 1.4212 | MIC | 1.2 | 1.0 | 0.7 | 1.4 |
| MBC | 2.5 | 3.0 | 1.5 | 3.5 | |||
| FC3 | (CH2)2CH3 | 2.7052 | MIC | 0.8 | 0.7 | 0.4 | 1.1 |
| MBC | 3.0 | 3.0 | 2.0 | 4.0 | |||
| FC6 | (CH2)5CH3 | 4.2922 | MIC | 0.5 | 0.4 | 0.4 | 1.1 |
| MBC | 3.0 | 3.0 | 2.0 | 4.0 | |||
| FC9 | (CH2)8CH3 | 5.8792 | MIC | 1.0 | 0.9 | 0.8 | 1.3 |
| MBC | 3.5 | 4.0 | 2.5 | 4.5 | |||
| FC12 | (CH2)11CH3 | 7.4662 | MIC | 3.3 | 2.8 | 2.6 | 3.5 |
| MBC | 5.0 | 4.5 | 4.0 | 5.0 |
ChemDraw 20.0 software was used for theoretical estimation.
FC3: 1H NMR (CDCl3, 400 MHz) δ 7.61 (d, J = 16.0 Hz, 1H), 7.07–7.01 (m, 2H), 6.29 (d, J = 16.0 Hz, 1H), 6.03 (s, 1H), 4.15 (t, J = 8.0 Hz, 1H), 3.90 (s, 1H), 1.76–1.67 (m, 2H), 0.98 (t, J = 8.0 Hz, 3H). 13C NMR (CDCl3, 100 MHz) δ 167.56, 148.09, 148.07, 146.92, 144.81, 126.89, 122.97, 115.39, 114.87, 109.46, 66.05, 55.85, 22.08, 10.44.
FC6: 1H NMR (400 MHz, CDCl3) δ 7.61 (d, J = 16.0 Hz, CH), 7.08–7.03 (m, 2CH), 6.91 (d, J = 7.6 Hz, CH), 6.29 (d, J = 16.0 Hz, CH), 5.88 (s, OH), 4.19 (t, J = 5.6 Hz, CH2), 3.93 (s, CH3), 1.69–1.33 (m, 4CH2), 0.90 (s, CH3). 13C NMR (100 MHz, CDCl3) δ 167.6, 148.0, 146.9, 144.8, 127.2, 123.2, 115.8, 114.8, 109.4, 64.8, 56.1, 31.6, 28.9, 25.8, 22.7, 14.2.
FC9: 1H NMR (400 MHz, CDCl3) δ 7.60 (d, J = 16.0 Hz, CH), 7.08–7.03 (m, 2CH), 6.91 (d, J = 8.4 Hz, CH), 6.29 (d, J = 15.6 Hz, CH), 5.95 (t, OH), 4.18 (t, 6.4 HZ, CH2), 3.92 (s, CH3),1.73–1.27(m, 7CH2). 0.88 (t, 6.8 HZ,CH3). 13C NMR (100 MHz, CDCl3) δ 167.4, 147.9, 146.7, 144.6, 127.0, 123.0, 115.7，114.7, 109.3, 64.6, 55.9, 31.9, 29.5, 29.3, 29.2, 28.8, 26.0, 22.7,14.1.
FC12: 1H NMR (CDCl3, 400 MHz) δ 7.61 (d, J = 16.0 Hz, 1H), 7.08–7.03 (m, 2H), 6.91 (d, J = 8.0 Hz, 1H), 6.29 (d, J = 16.0 Hz, 1H), 5.89 (s, 1H), 4.19 (t, J = 4.0 Hz, 2H), 3.92 (s, 1H), 1.73–1.66 (m, 2H), 1.26 (s, 18H), 0.88 (t, J = 4.0 Hz, 3H). 13C NMR (CDCl3, 100 MHz) δ 167.59, 148.08, 146.93, 144.82, 127.06, 123.11, 115.61, 114.88, 109.45, 64.74, 55.97, 32.00, 29.74, 29.72, 29.68, 29.63, 29.44, 29.39, 28.84, 26.08, 22.77, 14.20.