Table 5.
Predictive factors of developing IBD among participants with positive FIT who underwent colonoscopy.
| Univariable analysis | Multivariable analysis | |||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Findings of colonoscopy | ||||
| Negative | Ref | Ref | ||
| Positive | 1.18 (0.91,1.53) | .2054 | 1.22 (0.93,1.59) | .151 |
| Sex | ||||
| Female | Ref | Ref | ||
| Male | 1.33 (1.03,1.73) | .029 | 1.38 (1.03,1.84) | .0297 |
| Age at screening, years | ||||
| 50–59 | 2.55 (0.36,18.18) | .3519 | 3.04 (0.42,21.77) | .3519 |
| 60–69 | 2.05 (0.29,14.74) | .4753 | 2.36 (0.33,17.00) | .4753 |
| 70–79 | 1.81 (0.25,13.34) | .5611 | 1.99 (0.27,14.72) | .5611 |
| ≥80 | Ref | Ref | ||
| BMI | 0.92 (0.88,0.96) | .0003 | 0.92 (0.88,0.96) | .0003 |
| Smoking status | ||||
| No | Ref | Ref | ||
| Yes | 1.09 (0.78,1.52) | .6288 | 0.85 (0.59,1.23) | .3935 |
| Alcohol drinking | ||||
| No | Ref | Ref | ||
| Yes | 1.10 (0.81,1.47) | .5471 | 1.03 (0.74,1.43) | .8673 |
| Insurance type | ||||
| Medical aid | Ref | Ref | ||
| National health insurance | 0.37 (0.12,1.15) | .085 | 0.58 (0.24, 1.39) | .220 |
| Hypertension | ||||
| No | Ref | Ref | ||
| Yes | 0.93 (0.62,1.41) | .7424 | 1.03 (0.68,1.56) | .8937 |
| Diabetes | ||||
| No | Ref | Ref | ||
| Yes | 0.45 (0.21,0.95) | .0365 | 0.48 (0.22,1.02) | .0554 |
| Dyslipidaemia | ||||
| No | Ref | Ref | ||
| Yes | 0.83 (0.62,1.11) | .2006 | 0.74 (0.49,1.13) | .1673 |
| Abnormal total cholesterol | ||||
| No | Ref | Ref | ||
| Yes | 0.86 (0.63,1.18) | .3583 | 0.83 (0.51,1.36) | .458 |
| Abnormal triglyceride | ||||
| No | Ref | Ref | ||
| Yes | 0.84 (0.59,1.21) | .3495 | 1.07 (0.69,1.68) | .7561 |
| Abnormal HDL-cholesterol | ||||
| No | Ref | Ref. | ||
| Yes | 1.27 (0.90,1.8) | .1708 | 1.44 (0.99,2.09) | .0583 |
| Abnormal LDL-cholesterol | ||||
| No | Ref | Ref | ||
| Yes | 1.08 (0.79,1.47) | .6458 | 1.53 (0.97,2.41) | .0688 |
| Abnormal AST | ||||
| No | Ref | Ref | ||
| Yes | 0.72 (0.45,1.17) | .1841 | 0.74 (0.43,1.28) | .2842 |
| Abnormal ALT | ||||
| No | Ref | Ref | ||
| Yes | 0.86 (0.61,1.22) | .4083 | 1.03 (0.68,1.54) | .8966 |
IBD, inflammatory bowel disease; FIT, faecal immunochemical test; HR, hazard ratio; BMI, body mass index; HDL, high-density lipoprotein; LDL, low-density lipoprotein; AST, aspartate aminotransferase; ALT, alanine aminotransferase.