Table 2.
Comparison of biomarkers between the MDD group and HC group.
| Project | MDD (N=113) Mean ± SD/Median (IQR 25–75) |
HC (N=41) Mean ± SD/Median (IQR 25–75) |
p-value |
|---|---|---|---|
| proBDNF (ng/mL) | 2.936 ± 1.556 | 2.602 ± 1.330 | 0.368 |
| HMGB1 (pg/mL) | 117.995 ± 28.077 | 130.194 ± 26.379 | 0.018 |
| TNF-α (pg/mL) | 13.347 ± 1.241 | 12.901 ± 0.227 | 0 |
| BDNF (pg/mL) | 3.900 (2.491, 6.223) | 3.19 (0.2.313, 4.784) | 0.209 |
| hs-CRP (mg/L) | 2.347 (2.003, 2.656) | 2.300 (1.500, 2.675) | 0.463 |
| IL-4 (pg/mL) | 6.640 (4.494, 8.042) | 6.640 (4.081, 9.097) | 0.974 |
| IL-6 (pg/mL) | 2.106 (0.426, 2.727) | 0.421 (0.391, 0.572) | 0 |
| IL-10 (pg/mL) | 3.130 (2.699, 3.594) | 3.189 (2.752, 3.956) | 0.280 |
| IL-18 (pg/mL) | 3.465 (2.354, 5.690) | 4.104 (2.196, 5.714) | 0.792 |
| IL-23 (pg/mL) | 2.776 (2.286, 3.415) | 2.570 (2.071, 3.195) | 0.944 |
MDD, major depressive disorder; HC, healthy control; proBDNF, brain-derived neurotrophic factor precursor; HMGB1, high mobility group protein 1; TNF-α, tumor necrosis factor-α; BDNF, brain-derived neurotrophic factor; hs-CRP, hypersensitive C-reactive protein; IL, interleukin.