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. 2023 Jan 12;18(2):585–596. doi: 10.1016/j.stemcr.2022.12.012

Figure 5.

Figure 5

CAR-Ms (H9 derived) significantly reduce tumor burden in a CHLA-20 xenograft mouse model

(A) Schematic of mouse model experiments. CHLA-20-AkaLuc-GFP cells were injected subcutaneously alone or with WT-Ms or CAR-Ms. Luminescent signals were measured at 1, 8, 15, 22, and 29 days post injection. 10 mice per group.

(B) Tumor burden was assessed by bioluminescent imaging at indicated time points.

(C) Quantification of tumor burden as shown by luminescent signals. Results are represented as mean ± SD. Student’s t test; ∗p < 0.05; ns, not significant; n = 10 mice.

(D) Body weight represented as mean ± SD. Student’s t test; ns, not significant; n = 10 mice.