Figure 2.

GSK3β is a recurring drug target among the positive hits from the drug screen

(A) Outline of how drug targets were filtered. This was performed by removing drug targets with pIC50 <6 and then overall frequency lower than 5.

(B) Frequency of drug targets suggests that GSK3β (red) is a recurring target, among others.

(C) Heatmap of pIC50 values for all high-frequency drug targets indicates that GSK3β (arrow) is also a high-specificity drug target.

(D) Average pIC50 values for each drug target indicates that GSK3β (red) was the most specific target.

(E) Primary drug targets among the positive hits from the drug screen. GSK3β (red) is the most recurring primary target.