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. 2023 Jan 5;18(2):519–533. doi: 10.1016/j.stemcr.2022.12.001

Figure 1.

Figure 1

OPCs and microglia express Cx3cr1 mRNA in demyelinated brain

(A) Ten-week-old C57BL/6J mice were demyelinated with cuprizone chow for 6 weeks.

(B and D) RNA scope analysis of demyelinated brains for Cx3cr1 (red, B, D) and Pdgfrα (green, B) mRNAs or immunostained for IBA1 (green, D). White arrows and dashed lines indicate Cxc3r1+marker+ cells. Yellow arrowhead and dashed line indicate a Cx3cr1+marker- cell.

(C and E) RNA Scope analysis of midline CC from demyelinated brains with negative probe. Nuclei are visualized with DAPI (blue). Scale bars, 20 μm. n = 2 for each group.

See also Figure S1.