Table 1.

General studies information, patients’ characteristics, and study design of included studies.

Reference	Year	Study type	Arthroplasty joint	Thyroid disease, n		Sex, n		Age at TJA (years)		Follow-up (months)
				Patients	Control†	Female	Male	Patients	Control
Tan et al. (20)	2016	RO	Hip + Knee	4008	29,281	18,252	14,037	63.98		N/A
Althoff et al. (21)	2018	RO	Ankle	TAA: 6977; Hypothyroid: 2010		N/A	N/A	N/A		N/A
Buller et al. (7)	2018	RC	Knee	98,555	98,555	16,261	34,498	N/A		N/A
Shahi et al. (19)	2019	RO	Hip + Knee	4873		2714	2159	Hip: 65; Knee: 63.7		12
Somerson et al. (18)	2019	RC	Elbow	1452		1132	106	PJI: 62	60	3
Yuan et al. (16)	2020	RC	Knee	134	134	232	36	TD: 67.29	65.96	69.6
Yuan et al. (17)	2020	RC	Hip	63	63	68	58	TD 53.4	56.1	78
Jing et al. (14)	2021	CS	Knee	398	398	700	96	TD: 64.8	65.1	25.4
Yang. et al. (15)	2021	RO	Knee	PCR: 8484	1,218,760*	771,385	455,859	PCR: 64	67	N/A

*No PCRs; ^†includes non-thyroid disease.

CS, cohort study; PCR, prosthesis-related complications; PJI, periprosthetic joint infection; RC, retrospective cohort; RO, retrospective observational; TD, thyroid disease; TAA, total ankle arthroplasty; TJA, total joint arthroplasty.