TABLE 3.
Human bacteria with putative anticancer properties.
| Bacteria | cancer | Molecular mechanism |
|---|---|---|
| Lactobacillus | Colon cancer | Upregulated caspase‐3, caspase‐9, and Bax and down‐regulated Bcl2, cyclin D1, cyclin E, and ERBB2 genes. 26 , 269 |
| Bifidobacterium | Colon cancer | Induced the tumor suppressor miRNAs (miR‐145 and miR‐15a) expression. 26 , 269 |
| Clostridium butyricum | Colon cancer | Inhibited NF‐κB pathway and promoted apoptosis. 115 |
| Bacillus subtilis | Oral cancer | Inhibited PI3K/Akt/ NF‐κB and AP‐1/IL‐6 signaling pathways. 276 |
| Bifidobacteria | Colon cancer | Down‐regulated antiapoptotic genes and upregulated proapoptotic genes. 277 |
| Lactobacoilli | Cervical cancer | Upregulated E‐cadherin. 278 |
| Streptococcus thermophilus | Colorectal cancer | Secreted β‐galactosidase. 279 |
| Faecalibacterium prausnitzii | Colon cancer | Suppressed lipid peroxidation levels. 280 |