Table 2.
Coagulation and fibrinolytic markers of immune-mediated thrombotic thrombocytopenic purpura and septic disseminated intravascular coagulation.
| Coagulation/fibrinolytic marker | Reference | iTTPa | Septic DICa | P value |
|---|---|---|---|---|
| PT-INR | 0.90-1.15 | 1.08 (1.01-1.11) | 1.33 (1.11-1.60) | <.01 |
| aPTT (sec) | 24.0-37.7 | 31.0 (28.0-34.0) | 47.0 (32.3-82.5) | <.01 |
| Fibrinogen (mg/dL) | 200-400 | 310 (235-374) | 326 (213-553) | .73 |
| FDP (μg/mL) | <5.0 | 8.5 (4.3-16.9) | 43.4 (24.1-74.4) | <.01 |
| D-dimer (μg/mL) | <1.0 | 4.3 (1.5-7.7) | 17.9 (9.4-28.0) | <.01 |
| Antithrombin activity (%) | 80-100 | 100 (90-111) | 62 (48-81) | <.01 |
| TAT (ng/mL) | <3.9 | 9.6 (7.1-14.2) | 15.0 (7.5-28.3) | .11 |
| PIC (μg/mL) | <0.8 | 2.0 (1.2-2.6) | 2.5 (0.9-4.6) | .38 |
aPTT, activated partial thromboplastin time; DIC, disseminated intravascular coagulation; FDP, fibrin/fibrinogen degradation products; iTTP, immune thrombotic thrombocytopenic purpura; PIC, plasmin-α2 plasmin inhibitor complex; PT-INR, prothrombin time–international ratio; TAT, thrombin-antithrombin complex.
a
Each data point is described as median (first quartile to third quartile).