Table 3.
Comparison of characteristics of diabetes mellitus after total pancreatectomy and type 1 diabetes in the long-term follow-up period.
| Characteristics | TP(n = 80) | T1DM(n = 80) | P value |
|---|---|---|---|
| Age at last follow-up (years), mean ± SD | 62.59 ± 10.41 | 44.01 ± 17.22 | < 0.001 |
| Male, n (%) | 36 (45) | 30 (37.5) | 0.422 |
| Diabetes duration (months), median (IQR) | 20 (7, 63)* | 132 (72, 204) | < 0.001 |
| BMI (kg/m2), mean ± SD | 20.33 ± 2.39 | 20.92 ± 1.76 | 0.079 |
| HbA1c (%), mean ± SD | 7.43 ± 0.76 | 7.66 ± 1.12 | 0.128 |
| C-peptide (ng/ml), median (IQR) | <0.05 | <0.05 | – |
| Hypoglycemic events, n of patients/total n (%) | 47/80 (58.8) | 57/80 (71.3) | 0.097 |
| CGM measurements† | |||
| Mean glucose value (mmol/L), mean ± SD | 8.61 ± 1.59 | 8.25 ± 1.62 | 0.665 |
| SD (mmol/L), mean ± SD | 3.27 ± 0.71 | 3.24 ± 1.22 | 0.967 |
| CV (%), mean ± SD | 37.49 ± 8.26 | 38.22 ± 6.94 | 0.851 |
| Maximum glucose value (mmol/L), mean ± SD | 18.80 ± 3.51 | 17.71 ± 2.56 | 0.491 |
| Minimum glucose value (mmol/L), mean ± SD | 2.93 ± 0.56 | 3.20 ± 0.69 | 0.396 |
| TIR (%) (3.9-10 mmol/L), mean ± SD | 71.92 ± 9.43 | 70.19 ± 14.99 | 0.787 |
| TAR (%) (>10 mmol/L), mean ± SD | 23.41 ± 9.78 | 24.38 ± 14.51 | 0.877 |
| TBR (%) (<3.9 mmol/L), mean ± SD | 4.68 ± 4.54 | 5.42 ± 3.13 | 0.707 |
| Insulin regimen | |||
| Daily insulin dose (units/kg/day), mean ± SD | 0.49 ± 0.19 | 0.65 ± 0.19 | < 0.001 |
| Daily insulin dose (units/day), mean ± SD | 27.09 ± 11.88 | 38.74 ± 11.44 | < 0.001 |
| Basal percentage (%), mean ± SD | 39.4 ± 16.5 | 43.9 ± 9.9 | 0.035 |
| Insulin pump‡ | |||
| Daily insulin dose (units/kg/day), mean ± SD | 0.44 ± 0.14 | 0.66 ± 0.14 | < 0.001 |
| Daily insulin dose (units), mean ± SD | 24.81 ± 8.05 | 39.93 ± 10.22 | < 0.001 |
| Basal percentage (%), mean ± SD | 44.1 ± 14.5 | 49.8 ± 8.86 | 0.138 |
TP, total pancreatectomy; T1DM, type 1 diabetes mellitus; BMI, body mass index; HbA1c, glycosylated hemoglobin A1c; CGM, continuous glucose monitoring; SD, standard deviation of glucose; CV, coefficient of variation; TIR, time in range; TAR, time above range; TBR, time below range.
*Diabetes duration since total pancreatectomy.
†The CGM data were available in seven patients undergoing TP and eight with T1DM.
‡Insulin pumps were used in 14 patients after TP and 24 patients with T1DM.
P values < 0.05 were shown in bold.