TABLE 2.
Laboratory data of patients in the two cohorts.
| Variable | Younger adult cohort (n = 229) | Elderly cohort (n = 234) | p-value |
|---|---|---|---|
| Voriconazole C0 (0.5–5.0 μg/ml) | 3.00 (1.60, 4.81) | 3.64 (2.12, 5.50) | 0.027 |
| Voriconazole C0/CN | 1.33 (0.67, 3.11) | 1.85 (0.85, 3.23) | 0.307 |
| IL-6 (0–7 ng/L) | 23.9 (6.1, 75.0) | 39.9 (15.9, 106.8) | 0.001 |
| Platelet count (125–350 ×109/L) | 113 (39, 211) | 169 (96, 255) | <0.001 |
| Hemoglobin (115–150 g/L) | 87.6 ± 19.3 | 93.8 ± 19.0 | 0.001 |
| Liver function | |||
| ALP (38–126 U/L) | 100.0 (73.5, 147.9) | 114.7 (80.0, 159.0) | 0.170 |
| ALT (13–69 U/L) | 22.0 (10.4, 46.0) | 22.0 (12.0, 37.9) | 0.542 |
| AST (15–46 U/L) | 30.9 (18.3, 57.0) | 36.8 (24.1, 54.1) | 0.068 |
| γ-GT (12–58 U/L) | 69.4 (35.0, 151.2) | 86.5 (43.8, 169.6) | 0.082 |
| TBA (0–10 μmol/L) | 4.4 (2.2, 9.8) | 5.6 (3.0, 12.0) | 0.015 |
| Albumin (30–50 g/L) | 33.0 ± 5.6 | 33.1 ± 5.1 | 0.870 |
| TBIL (3–22 μmol/L) | 13.0 (8.9, 23.8) | 14.1 (9.8, 22.7) | 0.333 |
| DBIL (0–6 μmol/L) | 3.8 (1.7, 8.7) | 4.6 (2.5, 10.2) | 0.069 |
| IBIL (3–16 μmol/L) | 8.7 (5.9, 14.0) | 9.1 (6.8, 12.9) | 0.436 |
| Renal Function | |||
| Urea nitrogen (1.7–8.3 mmol/L) | 9.2 (6.0, 14.1) | 12.6 (5.5, 20.0) | 0.032 |
| Creatinine (59–104 μmol/L) | 81.2 (52.2, 151.5) | 75.2 (53.8, 126.0) | 0.555 |
| eGFR (80–120 ml/min) | 91.7 (41.0, 119.7) | 83.9 (46.1, 109.4) | 0.445 |
Data that do not conform to a normal distribution are represented by the median (interquartile range). Abbreviations: C0, trough concentrations of voriconazole; CN, trough concentrations of voriconazole-N-oxide; IL-6, interleukin-6; ALP, alkaline phosphatase; ALT, glutamic-pyruvic transaminase; AST, glutamic-oxalacetic transaminase; γ-GT, γ-glutamyl transferase; TBA, total bile acid; TBIL, total bilirubin; DBIL, direct bilirubin; IBIL, indirect bilirubin; eGFR, estimated glomerular filtration rate.